Part one of term paper
is an extremely rare genetic disease that was first identified in 1948 by W.L. Donohue. There have only been 49 cases reported worldwide since is first reporting in 1948 until 1987. This disease is also known as Donohue Syndrome, in his honor. Most patients die by the age of 10 months, although there have been cases of patients living unt ...

Part two of term paper
... growth is severely retarded. This is due to the patients being completely resistant to the effects of insulin. is an autosomal recessive, Mendelian inheritance pattern. As stated before, both males and females can be affected. Its occurrence is associated with consanguineous relationships. A consanguineous relationship means that the parents are genetically related (e.g. first cousins). Clinical traits are as follows:  Hyperpigmented skin or as otherwise known, Acanthosis nigricans. Th ...